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ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism

Inter-α-inhibitor heavy chain 4 (ITIH4) is a poorly characterized plasma protein that is proteolytically processed in multiple pathological conditions. However, no biological function of ITIH4 has been identified. Here, we show that ITIH4 is cleaved by several human proteases within a protease-susce...

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Publicat a:Sci Adv
Autors principals: Pihl, Rasmus, Jensen, Rasmus K., Poulsen, Emil C., Jensen, Lisbeth, Hansen, Annette G., Thøgersen, Ida B., Dobó, József, Gál, Péter, Andersen, Gregers R., Enghild, Jan J., Thiel, Steffen
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793589/
https://ncbi.nlm.nih.gov/pubmed/33523981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba7381
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