Urea-Peptide Hybrids as VEGF-A(165)/NRP-1 Complex Inhibitors with Improved Receptor Affinity and Biological Properties

Neuropilin-1 (NRP-1), the major co-receptor of vascular endothelial growth factor receptor-2 (VEGFR-2), may also independently act with VEGF-A(165) to stimulate tumour growth and metastasis. Therefore, there is great interest in compounds that can block VEGF-A165/NRP-1 interaction. Peptidomimetic ty...

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Pubblicato in:Int J Mol Sci
Autori principali: Puszko, Anna K., Sosnowski, Piotr, Rignault-Bricard, Rachel, Hermine, Olivier, Hopfgartner, Gérard, Pułka-Ziach, Karolina, Lepelletier, Yves, Misicka, Aleksandra
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793531/
https://ncbi.nlm.nih.gov/pubmed/33374715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22010072
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