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Does Cysteine Rule (CysR) Complete the CendR Principle? Increase in Affinity of Peptide Ligands for NRP-1 Through the Presence of N-Terminal Cysteine
The structure-activity relationship of branched H-Lys(hArg)-Dab-Dhp-Arg-OH sequence analogues, modified with Cys-Asp or Cys at N-terminal amino acids (Lys, hArg), in VEGF-A(165)/Neuropilin-1 complex inhibition is presented. The addition of Cys residue led to a 100-fold decrease in the IC(50) value,...
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| Publicado no: | Biomolecules |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7175122/ https://ncbi.nlm.nih.gov/pubmed/32183142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10030448 |
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