Multiobjective optimization identifies cancer-selective combination therapies

Combinatorial therapies are required to treat patients with advanced cancers that have become resistant to monotherapies through rewiring of redundant pathways. Due to a massive number of potential drug combinations, there is a need for systematic approaches to identify safe and effective combinatio...

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Bibliographic Details
Published in:PLoS Comput Biol
Main Authors: Pulkkinen, Otto I., Gautam, Prson, Mustonen, Ville, Aittokallio, Tero
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793282/
https://ncbi.nlm.nih.gov/pubmed/33370253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008538
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