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Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation

Mycobacterium tuberculosis (Mtb) infection causes tuberculosis (TB), a disease characterized by development of granulomas. Granulomas consist of activated immune cells that cluster together to limit bacterial growth and restrict dissemination. Control of the TB epidemic has been limited by lengthy d...

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Détails bibliographiques
Publié dans:PLoS Comput Biol
Auteurs principaux: Evans, Stephanie, Butler, J. Russell, Mattila, Joshua T., Kirschner, Denise E.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793262/
https://ncbi.nlm.nih.gov/pubmed/33370784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008520
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