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Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation

Mycobacterium tuberculosis (Mtb) infection causes tuberculosis (TB), a disease characterized by development of granulomas. Granulomas consist of activated immune cells that cluster together to limit bacterial growth and restrict dissemination. Control of the TB epidemic has been limited by lengthy d...

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Veröffentlicht in:PLoS Comput Biol
Hauptverfasser: Evans, Stephanie, Butler, J. Russell, Mattila, Joshua T., Kirschner, Denise E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793262/
https://ncbi.nlm.nih.gov/pubmed/33370784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008520
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