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Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation

Mycobacterium tuberculosis (Mtb) infection causes tuberculosis (TB), a disease characterized by development of granulomas. Granulomas consist of activated immune cells that cluster together to limit bacterial growth and restrict dissemination. Control of the TB epidemic has been limited by lengthy d...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Evans, Stephanie, Butler, J. Russell, Mattila, Joshua T., Kirschner, Denise E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793262/
https://ncbi.nlm.nih.gov/pubmed/33370784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008520
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