Overexpression of TGF-β1 induces renal fibrosis and accelerates the decline in kidney function in polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the presence of numerous fluid-filled cysts, extensive fibrosis, and the progressive decline in kidney function. Transforming growth factor-β1 (TGF-β1), an important mediator for renal fibrosis and chronic kidney disease, is ov...

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Publicat a:Am J Physiol Renal Physiol
Autors principals: Zhang, Yan, Dai, Yuqiao, Raman, Archana, Daniel, Emily, Metcalf, July, Reif, Gail, Pierucci-Alves, Fernando, Wallace, Darren P.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2020
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7792699/
https://ncbi.nlm.nih.gov/pubmed/33166182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00366.2020
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