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A serine loop in tissue factor mediates substrate selectivity by the tissue factor – factor VIIa complex
BACKGROUND: The tissue factor – factor VIIa (TF-FVIIa) complex is the physiologic activator of blood clotting and plays a major role in many thrombotic diseases. TF-FVIIa drives clotting through proteolytic cleavage of its major protein substrates, factor IX (FIX) and factor X (FX). However, it rema...
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| Udgivet i: | J Thromb Haemost |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7790960/ https://ncbi.nlm.nih.gov/pubmed/32885882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.15087 |
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