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TRF2 Mediates Replication Initiation within Human Telomeres to Prevent Telomere Dysfunction

The telomeric shelterin protein telomeric repeat-binding factor 2 (TRF2) recruits origin recognition complex (ORC) proteins, the foundational building blocks of DNA replication origins, to telomeres. We seek to determine whether TRF2-recruited ORC proteins give rise to functional origins in telomere...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Drosopoulos, William C., Deng, Zhong, Twayana, Shyam, Kosiyatrakul, Settapong T., Vladimirova, Olga, Lieberman, Paul M., Schildkraut, Carl L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790361/
https://ncbi.nlm.nih.gov/pubmed/33176153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108379
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