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TERRA G-quadruplex RNA interaction with TRF2 GAR domain is required for telomere integrity

Telomere dysfunction causes chromosomal instability which is associated with many cancers and age-related diseases. The non-coding telomeric repeat-containing RNA (TERRA) forms a structural and regulatory component of the telomere that is implicated in telomere maintenance and chromosomal end protec...

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Publicat a:Sci Rep
Autors principals: Mei, Yang, Deng, Zhong, Vladimirova, Olga, Gulve, Nitish, Johnson, F. Brad, Drosopoulos, William C., Schildkraut, Carl L., Lieberman, Paul M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876106/
https://ncbi.nlm.nih.gov/pubmed/33568696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-82406-x
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