Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway

We have previously shown that the microfilarial (mf) stage of Brugia malayi can inhibit the mammalian target of rapamycin (mTOR; a conserved serine/threonine kinase critical for immune regulation and cellular growth) in human dendritic cells (DC) and we have proposed that this mTOR inhibition is ass...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Ricciardi, Alessandra, Bennuru, Sasisekhar, Tariq, Sameha, Kaur, Sukhbir, Wu, Weiwei, Elkahloun, Abdel G., Arakelyan, Anush, Shaik, Jahangheer, Dorward, David W., Nutman, Thomas B., Tolouei Semnani, Roshanak
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7790274/
https://ncbi.nlm.nih.gov/pubmed/33411714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0008884
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