Microfilariae of Brugia malayi Inhibit the mTOR Pathway and Induce Autophagy in Human Dendritic Cells

Immune modulation is a hallmark of patent filarial infection, including suppression of antigen-presenting cell function and downmodulation of filarial antigen-specific T cell responses. The mammalian target of rapamycin (mTOR) signaling pathway has been implicated in immune regulation, not only by s...

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Détails bibliographiques
Publié dans:Infect Immun
Auteurs principaux: Narasimhan, Prakash Babu, Bennuru, Sasisekhar, Meng, Zhaojing, Cotton, Rachel N., Elliott, Kathleen R., Ganesan, Sundar, McDonald-Fleming, Renee, Veenstra, Timothy D., Nutman, Thomas B., Tolouei Semnani, Roshanak
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
Sujets:
Host Response and Inflammation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995918/
https://ncbi.nlm.nih.gov/pubmed/27297394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00174-16
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