Deletion of cardiac polycystin 2/PC2 results in increased SR calcium release and blunted adrenergic reserve

Transient receptor potential proteins (TRPs) act as nonselective cation channels. Of the TRP channels, PC2 (also known as polycystin 2) is localized to the sarcoplasmic reticulum (SR); however, its contribution to calcium-induced calcium release and overall cardiac function in the heart is poorly un...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: DiNello, Elisabeth, Bovo, Elisa, Thuo, Paula, Martin, Thomas G., Kirk, Jonathan A., Zima, Aleksey V., Cao, Quan, Kuo, Ivana Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7789970/
https://ncbi.nlm.nih.gov/pubmed/32946258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00302.2020
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