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The role of RyR2 oxidation in the blunted frequency-dependent facilitation of Ca(2+) transient amplitude in rabbit failing myocytes
Defective Ca(2+) regulation play a key role in the blunted force-frequency response in heart failure (HF). Since HF is commonly associated with oxidative stress, we studied whether oxidation of ryanodine receptor (RyR2) contributes to this defect. In control ventricular myocytes, oxidative stress in...
Gardado en:
| Publicado en: | Pflugers Arch |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5948141/ https://ncbi.nlm.nih.gov/pubmed/29500669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-018-2122-3 |
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