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Oxidation of ryanodine receptor after ischemia-reperfusion increases propensity of Ca(2+) waves during β-adrenergic receptor stimulation
β-Adrenergic receptor (β-AR) activation produces the main positive inotropic response of the heart. During ischemia-reperfusion (I/R), however, β-AR activation can trigger life-threatening arrhythmias. Because I/R is frequently associated with oxidative stress, we investigated whether ryanodine rece...
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| Publicado en: | Am J Physiol Heart Circ Physiol |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Physiological Society
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6230903/ https://ncbi.nlm.nih.gov/pubmed/30028204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00334.2018 |
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