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Oxidation of ryanodine receptor after ischemia-reperfusion increases propensity of Ca(2+) waves during β-adrenergic receptor stimulation

β-Adrenergic receptor (β-AR) activation produces the main positive inotropic response of the heart. During ischemia-reperfusion (I/R), however, β-AR activation can trigger life-threatening arrhythmias. Because I/R is frequently associated with oxidative stress, we investigated whether ryanodine rece...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Bovo, Elisa, Mazurek, Stefan R., Zima, Aleksey V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230903/
https://ncbi.nlm.nih.gov/pubmed/30028204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00334.2018
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