Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy

BACKGROUND: Immunotherapy with checkpoint inhibitors has shown impressive results in patients with melanoma, but still many do not benefit from this line of treatment. A lack of tumor-infiltrating T cells is a common reason for therapy failure but also a loss of intratumoral dendritic cells (DCs) ha...

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Detalles Bibliográficos
Publicado en:J Immunother Cancer
Main Authors: Prokopi, Anastasia, Tripp, Christoph H, Tummers, Bart, Hornsteiner, Florian, Spoeck, Sarah, Crawford, Jeremy Chase, Clements, Derek R, Efremova, Mirjana, Hutter, Katharina, Bellmann, Lydia, Cappellano, Giuseppe, Cadilha, Bruno L, Kobold, Sebastian, Boon, Louis, Ortner, Daniela, Trajanoski, Zlatko, Chen, Suzie, de Gruijl, Tanja D, Idoyaga, Juliana, Green, Douglas R, Stoitzner, Patrizia
Formato: Artigo
Idioma:Inglês
Publicado: BMJ Publishing Group 2021
Assuntos:
Immune Cell Therapies and Immune Cell Engineering
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7789456/
https://ncbi.nlm.nih.gov/pubmed/33408092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000832
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