Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy

BACKGROUND: Immunotherapy with checkpoint inhibitors has shown impressive results in patients with melanoma, but still many do not benefit from this line of treatment. A lack of tumor-infiltrating T cells is a common reason for therapy failure but also a loss of intratumoral dendritic cells (DCs) ha...

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Veröffentlicht in:J Immunother Cancer
Hauptverfasser: Prokopi, Anastasia, Tripp, Christoph H, Tummers, Bart, Hornsteiner, Florian, Spoeck, Sarah, Crawford, Jeremy Chase, Clements, Derek R, Efremova, Mirjana, Hutter, Katharina, Bellmann, Lydia, Cappellano, Giuseppe, Cadilha, Bruno L, Kobold, Sebastian, Boon, Louis, Ortner, Daniela, Trajanoski, Zlatko, Chen, Suzie, de Gruijl, Tanja D, Idoyaga, Juliana, Green, Douglas R, Stoitzner, Patrizia
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2021
Schlagworte:
Immune Cell Therapies and Immune Cell Engineering
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7789456/
https://ncbi.nlm.nih.gov/pubmed/33408092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000832
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