USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells

Altering ubiquitination by disruption of deubiquitinating enzymes (DUBs) affects hematopoietic stem cell (HSC) maintenance. However, comprehensive knowledge of DUB function during hematopoiesis in vivo is lacking. Here, we systematically inactivate DUBs in mouse hematopoietic progenitors using in vi...

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Publicat a:Cell Rep
Autors principals: van den Berk, Paul, Lancini, Cesare, Company, Carlos, Serresi, Michela, Sanchez-Bailon, Maria Pilar, Hulsman, Danielle, Pritchard, Colin, Song, Ji-Ying, Schmitt, Matthias Jürgen, Tanger, Ellen, Popp, Oliver, Mertins, Philipp, Huijbers, Ivo J., Jacobs, Heinz, van Lohuizen, Maarten, Gargiulo, Gaetano, Citterio, Elisabetta
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7788286/
https://ncbi.nlm.nih.gov/pubmed/33378683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108533
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