Compound C Protects Against Cisplatin-Induced Nephrotoxicity Through Pleiotropic Effects

AICAR (Acadesine/AICA riboside) as an activator of AMPK, can protect renal tubular cells from cisplatin induced apoptosis. But in our experiment, the dorsomorphin (compound C, an inhibitor of AMPK) also significantly reduced cisplatin induced renal tubular cells apoptosis. Accordingly, we tested whe...

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Publicado en:Front Physiol
Autores principales: Li, Fanghua, Sun, Anbang, Cheng, Genyang, Liu, Dong, Xiao, Jing, Zhao, Zhanzheng, Dong, Zheng
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785967/
https://ncbi.nlm.nih.gov/pubmed/33424637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.614244
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