Compound C Protects Against Cisplatin-Induced Nephrotoxicity Through Pleiotropic Effects

AICAR (Acadesine/AICA riboside) as an activator of AMPK, can protect renal tubular cells from cisplatin induced apoptosis. But in our experiment, the dorsomorphin (compound C, an inhibitor of AMPK) also significantly reduced cisplatin induced renal tubular cells apoptosis. Accordingly, we tested whe...

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Dettagli Bibliografici
Pubblicato in:Front Physiol
Autori principali: Li, Fanghua, Sun, Anbang, Cheng, Genyang, Liu, Dong, Xiao, Jing, Zhao, Zhanzheng, Dong, Zheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Physiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785967/
https://ncbi.nlm.nih.gov/pubmed/33424637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.614244
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