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Compound C Protects Against Cisplatin-Induced Nephrotoxicity Through Pleiotropic Effects

AICAR (Acadesine/AICA riboside) as an activator of AMPK, can protect renal tubular cells from cisplatin induced apoptosis. But in our experiment, the dorsomorphin (compound C, an inhibitor of AMPK) also significantly reduced cisplatin induced renal tubular cells apoptosis. Accordingly, we tested whe...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Physiol
Prif Awduron: Li, Fanghua, Sun, Anbang, Cheng, Genyang, Liu, Dong, Xiao, Jing, Zhao, Zhanzheng, Dong, Zheng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7785967/
https://ncbi.nlm.nih.gov/pubmed/33424637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.614244
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