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Granzyme B induces IRF-3 phosphorylation through a perforin-independent proteolysis-dependent signaling cascade without inducing cell death
Granzyme B (GrB) is an immune protease implicated in the pathogenesis of several human diseases. In the current model of GrB activity, perforin determines whether the downstream actions of GrB occur intracellularly or extracellularly, producing apoptotic cytotoxicity or non-apoptotic effects respect...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | J Immunol |
|---|---|
| Prif Awduron: | , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2020
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7785649/ https://ncbi.nlm.nih.gov/pubmed/33288544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000546 |
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