The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice

BACKGROUND: Molecular tweezers (MTs) are broad-spectrum inhibitors of abnormal protein aggregation. A lead MT, called CLR01, has been demonstrated to inhibit the aggregation and toxicity of multiple amyloidogenic proteins in vitro and in vivo. Previously, we evaluated the effect of CLR01 in the 3 × ...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Di, Jing, Siddique, Ibrar, Li, Zizheng, Malki, Ghattas, Hornung, Simon, Dutta, Suman, Hurst, Ian, Ishaaya, Ella, Wang, Austin, Tu, Sally, Boghos, Ani, Ericsson, Ida, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7784007/
https://ncbi.nlm.nih.gov/pubmed/33397489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-020-00743-x
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