The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice

BACKGROUND: Molecular tweezers (MTs) are broad-spectrum inhibitors of abnormal protein aggregation. A lead MT, called CLR01, has been demonstrated to inhibit the aggregation and toxicity of multiple amyloidogenic proteins in vitro and in vivo. Previously, we evaluated the effect of CLR01 in the 3 × ...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Alzheimers Res Ther
Prif Awduron: Di, Jing, Siddique, Ibrar, Li, Zizheng, Malki, Ghattas, Hornung, Simon, Dutta, Suman, Hurst, Ian, Ishaaya, Ella, Wang, Austin, Tu, Sally, Boghos, Ani, Ericsson, Ida, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2021
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7784007/
https://ncbi.nlm.nih.gov/pubmed/33397489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-020-00743-x
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