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Targeting c-kit inhibits gefitinib resistant NSCLC cell growth and invasion through attenuations of stemness, EMT and acquired resistance

EGFR tyrosine kinase inhibitors (TKIs) are the first-line drugs for NSCLC. But, the acquired resistance limited their efficacy, so that the patients deteriorate eventually. Therefore, it is necessary to clarify the mechanism of the acquired resistance and overcome it for effective NSCLC therapy. In...

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Detalhes bibliográficos
Publicado no:Am J Cancer Res
Main Authors: Zhou, Yueling, Wang, Li, Sun, Zhen, Zhang, Jie, Wang, Xiujie
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7783754/
https://ncbi.nlm.nih.gov/pubmed/33414998
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