Gefitinib Inhibits Invasive Phenotype and Epithelial-Mesenchymal Transition in Drug-Resistant NSCLC Cells with MET Amplification

Despite the initial response, all patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) eventually develop acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). The EGFR-T790M secondary mutation is responsible for half of acquired resistance cases,...

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Main Authors: La Monica, Silvia, Caffarra, Cristina, Saccani, Francesca, Galvani, Elena, Galetti, Maricla, Fumarola, Claudia, Bonelli, Mara, Cavazzoni, Andrea, Cretella, Daniele, Sirangelo, Rita, Gatti, Rita, Tiseo, Marcello, Ardizzoni, Andrea, Giovannetti, Elisa, Petronini, Pier Giorgio, Alfieri, Roberta R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805532/
https://ncbi.nlm.nih.gov/pubmed/24167634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078656
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