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Triplex-Forming Peptide Nucleic Acids with Extended Backbones

Peptide nucleic acid (PNA) forms a triple helix with double-stranded RNA (dsRNA) stabilized by a hydrogen-bonding zipper formed by PNA’s backbone amides (N-H) interacting with RNA phosphate oxygens. This hydrogen-bonding pattern is enabled by the matching ~5.7 Å spacing (typical for A-form dsRNA) be...

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Bibliografiska uppgifter
I publikationen:Chembiochem
Huvudupphovsmän: Kumar, Vipin, Brodyagin, Nikita, Rozners, Eriks
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7783598/
https://ncbi.nlm.nih.gov/pubmed/32697857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000432
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