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Relevance of Higher-Order Epistasis in Drug Resistance
We studied five chemically distinct but related 1,3,5-triazine antifolates with regard to their effects on growth of a set of mutants in dihydrofolate reductase. The mutants comprise a combinatorially complete data set of all 16 possible combinations of four amino acid replacements associated with r...
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| 出版年: | Mol Biol Evol |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7782864/ https://ncbi.nlm.nih.gov/pubmed/32745183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msaa196 |
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