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Proteostasis Environment Shapes Higher-Order Epistasis Operating on Antibiotic Resistance

Recent studies have affirmed that higher-order epistasis is ubiquitous and can have large effects on complex traits. Yet, we lack frameworks for understanding how epistatic interactions are influenced by central features of cell physiology. In this study, we assess how protein quality control machin...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Guerrero, Rafael F., Scarpino, Samuel V., Rodrigues, João V., Hartl, Daniel L., Ogbunugafor, C. Brandon
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553834/
https://ncbi.nlm.nih.gov/pubmed/31015194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.119.302138
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