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High-order epistasis shapes evolutionary trajectories
High-order epistasis—where the effect of a mutation is determined by interactions with two or more other mutations—makes small, but detectable, contributions to genotype-fitness maps. While epistasis between pairs of mutations is known to be an important determinant of evolutionary trajectories, the...
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| Veröffentlicht in: | PLoS Comput Biol |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5448810/ https://ncbi.nlm.nih.gov/pubmed/28505183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005541 |
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