The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus

CD4 and CD8 mark helper and cytotoxic T cell lineages, respectively, and serve as coreceptors for MHC-restricted TCR recognition. How coreceptor expression is matched with TCR specificity is central to understanding CD4/CD8 lineage choice, but visualising coreceptor gene activity in individual selec...

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Published in:Nat Commun
Main Authors: Karimi, Mohammad M., Guo, Ya, Cui, Xiaokai, Pallikonda, Husayn A., Horková, Veronika, Wang, Yi-Fang, Gil, Sara Ruiz, Rodriguez-Esteban, Gustavo, Robles-Rebollo, Irene, Bruno, Ludovica, Georgieva, Radina, Patel, Bhavik, Elliott, James, Dore, Marian H., Dauphars, Danielle, Krangel, Michael S., Lenhard, Boris, Heyn, Holger, Fisher, Amanda G., Štěpánek, Ondřej, Merkenschlager, Matthias
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7782583/
https://ncbi.nlm.nih.gov/pubmed/33397934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20306-w
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