A non-human primate in vitro functional assay for the early evaluation of TB vaccine candidates

We present a non-human primate mycobacterial growth inhibition assay (MGIA) using in vitro blood or cell co-culture with the aim of refining and expediting early tuberculosis vaccine testing. We have taken steps to optimise the assay using cryopreserved peripheral blood mononuclear cells, transfer i...

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Detalhes bibliográficos
Publicado no:NPJ Vaccines
Main Authors: Tanner, Rachel, White, Andrew D., Boot, Charelle, Sombroek, Claudia C., O’Shea, Matthew K., Wright, Daniel, Hoogkamer, Emily, Bitencourt, Julia, Harris, Stephanie A., Sarfas, Charlotte, Wittenberg, Rachel, Satti, Iman, Fletcher, Helen A., Verreck, Frank A. W., Sharpe, Sally A., McShane, Helen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7782578/
https://ncbi.nlm.nih.gov/pubmed/33397986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-020-00263-7
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