Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome

Previous work has revealed that progerin-lamin A binding inhibitor (JH4) can ameliorate pathological features of Hutchinson-Gilford progeria syndrome (HGPS) such as nuclear deformation, growth suppression in patient’s cells, and very short life span in an in vivo mouse model. Despite its favorable e...

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Vydáno v:Commun Biol
Hlavní autoři: Kang, So-mi, Yoon, Min-Ho, Ahn, Jinsook, Kim, Ji-Eun, Kim, So Young, Kang, Seock Yong, Joo, Jeongmin, Park, Soyoung, Cho, Jung-Hyun, Woo, Tae-Gyun, Oh, Ah-Young, Chung, Kyu Jin, An, So Yon, Hwang, Tae Sung, Lee, Soo Yong, Kim, Jeong-Su, Ha, Nam-Chul, Song, Gyu-Yong, Park, Bum-Joon
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7782499/
https://ncbi.nlm.nih.gov/pubmed/33398110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01540-w
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