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Allosteric autoactivation of SOS and its kinetic mechanism
Son of Sevenless (SOS), one of guanine nucleotide exchange factors (GEFs), activates Ras. We discovered that the allosteric domain of SOS yields SOS to proceed a previously unrecognized autoactivation kinetics. Its essential feature is a time-dependent acceleration of SOS feedback activation with a...
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| Publicado no: | Small GTPases |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7781538/ https://ncbi.nlm.nih.gov/pubmed/30983499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541248.2019.1601954 |
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