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Kinetic Mechanisms of Mutation-dependent Harvey Ras Activation and Their Relevance for Development of Costello Syndrome
Costello syndrome is linked to activating mutations of a residue in the p-loop or the NKCD/SAK motifs of Harvey Ras (HRas). More than 10 HRas mutants that induce Costello syndrome have been identified; G12S HRas is the most prevalent of these. However, certain HRas p-loop mutations also are linked t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3918454/ https://ncbi.nlm.nih.gov/pubmed/24224811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400679q |
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