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Lung Myofibroblasts Promote Macrophage Profibrotic Activity through Lactate-induced Histone Lactylation
Augmented glycolysis due to metabolic reprogramming in lung myofibroblasts is critical to their profibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into the extracellular milieu, together with which myofibroblasts and macrophages form a spatially restricted site usuall...
שמור ב:
| הוצא לאור ב: | Am J Respir Cell Mol Biol |
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| Main Authors: | , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Thoracic Society
2021
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7780997/ https://ncbi.nlm.nih.gov/pubmed/33074715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2020-0360OC |
| תגים: |
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