Lung Myofibroblasts Promote Macrophage Profibrotic Activity through Lactate-induced Histone Lactylation

Augmented glycolysis due to metabolic reprogramming in lung myofibroblasts is critical to their profibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into the extracellular milieu, together with which myofibroblasts and macrophages form a spatially restricted site usuall...

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Dettagli Bibliografici
Pubblicato in:Am J Respir Cell Mol Biol
Autori principali: Cui, Huachun, Xie, Na, Banerjee, Sami, Ge, Jing, Jiang, Dingyuan, Dey, Tapan, Matthews, Qiana L., Liu, Rui-Ming, Liu, Gang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2021
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780997/
https://ncbi.nlm.nih.gov/pubmed/33074715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2020-0360OC
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