Inhibition of the proteasome and proteaphagy enhances apoptosis in FLT3‐ITD‐driven acute myeloid leukemia

Acute myeloid leukaemia (AML) is a clonal disorder that affects hematopoietic stem cells or myeloid progenitors. One of the most common mutations that results in AML occurs in the gene encoding fms‐like tyrosine kinase 3 (FLT3). Previous studies have demonstrated that AML cells expressing FLT3‐inter...

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Publicat a:FEBS Open Bio
Autors principals: Lopez‐Reyes, Rosa G., Quinet, Grégoire, Gonzalez‐Santamarta, Maria, Larrue, Clément, Sarry, Jean‐Emmanuel, Rodriguez, Manuel S.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780102/
https://ncbi.nlm.nih.gov/pubmed/33410599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12950
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