dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA‐repair‐defective human cancer cells

Deficiency in DNA repair proteins confers susceptibility to DNA damage, making cancer cells vulnerable to various cancer chemotherapies. 5‐Fluorouracil (5‐FU) is an anticancer nucleoside analog that both inhibits thymidylate synthase (TS) and causes DNA damage via the misincorporation of FdUTP and d...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancer Sci
Main Authors: Yokogawa, Tatsushi, Yano, Wakako, Tsukioka, Sayaka, Osada, Akiko, Wakasa, Takeshi, Ueno, Hiroyuki, Hoshino, Takuya, Yamamura, Keisuke, Fujioka, Akio, Fukuoka, Masayoshi, Ohkubo, Shuichi, Matsuo, Kenichi
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Drug Discovery and Delivery
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780055/
https://ncbi.nlm.nih.gov/pubmed/33140501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14718
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