dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA‐repair‐defective human cancer cells

Deficiency in DNA repair proteins confers susceptibility to DNA damage, making cancer cells vulnerable to various cancer chemotherapies. 5‐Fluorouracil (5‐FU) is an anticancer nucleoside analog that both inhibits thymidylate synthase (TS) and causes DNA damage via the misincorporation of FdUTP and d...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Yokogawa, Tatsushi, Yano, Wakako, Tsukioka, Sayaka, Osada, Akiko, Wakasa, Takeshi, Ueno, Hiroyuki, Hoshino, Takuya, Yamamura, Keisuke, Fujioka, Akio, Fukuoka, Masayoshi, Ohkubo, Shuichi, Matsuo, Kenichi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Drug Discovery and Delivery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780055/
https://ncbi.nlm.nih.gov/pubmed/33140501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14718
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