dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA‐repair‐defective human cancer cells

Deficiency in DNA repair proteins confers susceptibility to DNA damage, making cancer cells vulnerable to various cancer chemotherapies. 5‐Fluorouracil (5‐FU) is an anticancer nucleoside analog that both inhibits thymidylate synthase (TS) and causes DNA damage via the misincorporation of FdUTP and d...

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Bibliographic Details
Published in:Cancer Sci
Main Authors: Yokogawa, Tatsushi, Yano, Wakako, Tsukioka, Sayaka, Osada, Akiko, Wakasa, Takeshi, Ueno, Hiroyuki, Hoshino, Takuya, Yamamura, Keisuke, Fujioka, Akio, Fukuoka, Masayoshi, Ohkubo, Shuichi, Matsuo, Kenichi
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Drug Discovery and Delivery
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780055/
https://ncbi.nlm.nih.gov/pubmed/33140501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14718
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