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The dUTPase Enzyme Is Essential in Mycobacterium smegmatis
Thymidine biosynthesis is essential in all cells. Inhibitors of the enzymes involved in this pathway (e.g. methotrexate) are thus frequently used as cytostatics. Due to its pivotal role in mycobacterial thymidylate synthesis dUTPase, which hydrolyzes dUTP into the dTTP precursor dUMP, has been sugge...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3360063/ https://ncbi.nlm.nih.gov/pubmed/22655049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037461 |
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