A Hidden Active Site in the Potential Drug Target Mycobacterium tuberculosis dUTPase Is Accessible through Small Amplitude Protein Conformational Changes

dUTPases catalyze the hydrolysis of dUTP into dUMP and pyrophosphate to maintain the proper nucleotide pool for DNA metabolism. Recent evidence suggests that dUTPases may also represent a selective drug target in mycobacteria because of the crucial role of these enzymes in maintaining DNA integrity....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lopata, Anna, Leveles, Ibolya, Bendes, Ábris Ádám, Viskolcz, Béla, Vértessy, Beáta G., Jójárt, Balázs, Tóth, Judit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159494/
https://ncbi.nlm.nih.gov/pubmed/27815500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.734012
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