A Hidden Active Site in the Potential Drug Target Mycobacterium tuberculosis dUTPase Is Accessible through Small Amplitude Protein Conformational Changes

dUTPases catalyze the hydrolysis of dUTP into dUMP and pyrophosphate to maintain the proper nucleotide pool for DNA metabolism. Recent evidence suggests that dUTPases may also represent a selective drug target in mycobacteria because of the crucial role of these enzymes in maintaining DNA integrity....

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Lopata, Anna, Leveles, Ibolya, Bendes, Ábris Ádám, Viskolcz, Béla, Vértessy, Beáta G., Jójárt, Balázs, Tóth, Judit
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Enzymology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159494/
https://ncbi.nlm.nih.gov/pubmed/27815500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.734012
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