A Hidden Active Site in the Potential Drug Target Mycobacterium tuberculosis dUTPase Is Accessible through Small Amplitude Protein Conformational Changes

dUTPases catalyze the hydrolysis of dUTP into dUMP and pyrophosphate to maintain the proper nucleotide pool for DNA metabolism. Recent evidence suggests that dUTPases may also represent a selective drug target in mycobacteria because of the crucial role of these enzymes in maintaining DNA integrity....

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Lopata, Anna, Leveles, Ibolya, Bendes, Ábris Ádám, Viskolcz, Béla, Vértessy, Beáta G., Jójárt, Balázs, Tóth, Judit
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2016
Konular:
Enzymology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159494/
https://ncbi.nlm.nih.gov/pubmed/27815500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.734012
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