Roles of CCR2 and CCR5 for Hepatic Macrophage Polarization in Mice With Liver Parenchymal Cell-Specific NEMO Deletion

BACKGROUND & AIMS: Macrophages are key regulators of inflammation and cancer promotion in the liver, and their recruitment and activation is linked to chemokine receptor signaling. However, the exact roles of the chemokine receptors CCR2 and CCR5 for macrophage functions in the liver is obscure....

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Veröffentlicht in:Cell Mol Gastroenterol Hepatol
Hauptverfasser: Bartneck, Matthias, Koppe, Christiane, Fech, Viktor, Warzecha, Klaudia T., Kohlhepp, Marlene, Huss, Sebastian, Weiskirchen, Ralf, Trautwein, Christian, Luedde, Tom, Tacke, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7779787/
https://ncbi.nlm.nih.gov/pubmed/32896623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.08.012
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