CD137 Agonist-based Combination Immunotherapy Enhances Activated, Effector Memory T cells and Prolongs Survival in Pancreatic Adenocarcinoma

Pancreatic ductal adenocarcinoma(PDAC) is resistant to the PD-1/PD-L1 blockade therapy. Previously, the combination of PD-1 blockade and vaccine therapy was shown to have a modest antitumor activity in murine models of PDAC. We used a murine syngeneic model of metastatic PDAC to identify, among mult...

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Veröffentlicht in:Cancer Lett
Hauptverfasser: Muth, Stephen T., Saung, May Tun, Blair, Alex B., Henderson, MacKenzie G., Thomas, Dwayne L., Zheng, Lei
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7779747/
https://ncbi.nlm.nih.gov/pubmed/33271264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2020.11.041
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