Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer

BACKGROUND: The pancreatic cancer vaccine, GVAX, induces novel lymphoid aggregates in the otherwise immune quiescent pancreatic ductal adenocarcinoma (PDAC). GVAX also upregulates the PD-1/PD-L1 pathway, and a pre-clinical model demonstrated the anti-tumor effects of combination GVAX and anti-PD-1 a...

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Udgivet i:J Immunother Cancer
Main Authors: Saung, May Tun, Muth, Stephen, Ding, Ding, Thomas, Dwayne L., Blair, Alex B., Tsujikawa, Takahiro, Coussens, Lisa, Jaffee, Elizabeth M., Zheng, Lei
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234697/
https://ncbi.nlm.nih.gov/pubmed/30424804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-018-0435-6
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