Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer

BACKGROUND: The pancreatic cancer vaccine, GVAX, induces novel lymphoid aggregates in the otherwise immune quiescent pancreatic ductal adenocarcinoma (PDAC). GVAX also upregulates the PD-1/PD-L1 pathway, and a pre-clinical model demonstrated the anti-tumor effects of combination GVAX and anti-PD-1 a...

Full description

Saved in:
Bibliographic Details
Published in:J Immunother Cancer
Main Authors: Saung, May Tun, Muth, Stephen, Ding, Ding, Thomas, Dwayne L., Blair, Alex B., Tsujikawa, Takahiro, Coussens, Lisa, Jaffee, Elizabeth M., Zheng, Lei
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234697/
https://ncbi.nlm.nih.gov/pubmed/30424804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-018-0435-6
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items