Megadalton-sized Dityrosine Aggregates of α-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics

Heterogeneous aggregates of the human protein α-synuclein (αSyn) are abundantly found in Lewy body inclusions of Parkinson’s disease patients. While structural information on classical αSyn amyloid fibrils is available, little is known about the conformational properties of disease-relevant, non-can...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Mol Biol
Prif Awduron: Verzini, Silvia, Shah, Maliha, Theillet, Francois-Xavier, Belsom, Adam, Bieschke, Jan, Wanker, Erich E., Rappsilber, Juri, Binolfi, Andres, Selenko, Philipp
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7779668/
https://ncbi.nlm.nih.gov/pubmed/33211011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.10.023
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