Megadalton-sized Dityrosine Aggregates of α-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics

Heterogeneous aggregates of the human protein α-synuclein (αSyn) are abundantly found in Lewy body inclusions of Parkinson’s disease patients. While structural information on classical αSyn amyloid fibrils is available, little is known about the conformational properties of disease-relevant, non-can...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Verzini, Silvia, Shah, Maliha, Theillet, Francois-Xavier, Belsom, Adam, Bieschke, Jan, Wanker, Erich E., Rappsilber, Juri, Binolfi, Andres, Selenko, Philipp
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7779668/
https://ncbi.nlm.nih.gov/pubmed/33211011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.10.023
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