Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites

Cellular oxidative stress serves as a common denominator in many neurodegenerative disorders, including Parkinson's disease. Here we use in-cell NMR spectroscopy to study the fate of the oxidation-damaged Parkinson's disease protein alpha-synuclein (α-Syn) in non-neuronal and neuronal mamm...

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Pubblicato in:Nat Commun
Autori principali: Binolfi, Andres, Limatola, Antonio, Verzini, Silvia, Kosten, Jonas, Theillet, Francois-Xavier, May Rose, Honor, Bekei, Beata, Stuiver, Marchel, van Rossum, Marleen, Selenko, Philipp
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737712/
https://ncbi.nlm.nih.gov/pubmed/26807843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10251
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