Thermodynamics of protein destabilization in live cells

Although protein folding and stability have been well explored under simplified conditions in vitro, it is yet unclear how these basic self-organization events are modulated by the crowded interior of live cells. To find out, we use here in-cell NMR to follow at atomic resolution the thermal unfoldi...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Danielsson, Jens, Mu, Xin, Lang, Lisa, Wang, Huabing, Binolfi, Andres, Theillet, François-Xavier, Bekei, Beata, Logan, Derek T., Selenko, Philipp, Wennerström, Håkan, Oliveberg, Mikael
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603463/
https://ncbi.nlm.nih.gov/pubmed/26392565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511308112
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